Drug Standards
Medchemexpress LLC Haloperidol | 52-86-8 | 99.8% | C₂₁H₂₃ClFNO₂ | 100 MG
This product is an analytical standard suitable for research and analytical applications. It functions as a potent antagonist for dopamine D2 receptors and is commonly employed in qualitative, quantitative, and methodological research experiments, including techniques such as HPLC, GC, and MS.
- Intended for research and analytical use.
- Dopamine D2 receptor antagonist.
- Utilized in various analytical research methods.
Medchemexpress LLC Citalopram hydrobromide | 59729-32-7 | 99.87% | 5 MG
Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI) that exhibits blood-brain barrier permeability. It inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM and in rabbit blood platelets with an IC50 of 14 nM, demonstrating an antidepressant effect.
- Selective serotonin reuptake inhibitor
- Permeates the blood-brain barrier
- Inhibits 5-HT uptake into synaptosomes
- Inhibits 5-HT uptake in rabbit blood platelets
- Exhibits antidepressant effects
- For research use only
Selleck Chemical LLC Flavopiridol (Alvocidib) S1230-10mM/1mL
Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1 CDK2 CDK4 CDK6 and CDK9 with IC50 values in the 20-100 nM range It is more selective for CDK1 2 4 6 9 versus CDK7 Flavopiridol is initially found to inhibit EGFR and PKA Flavopiridol induces autophagy and ER stress Flavopiridol blocks HIV-1 replication Phase 1/2
Apexbio Technology LLC Bromfenac Sodium 91714-93-1 10mM (in 1mL DMSO)
Bromfenac Sodium (CAS 91714-93-1) is a nonsteroidal anti-inflammatory small molecule compound characterized primarily by its capacity to inhibit cyclooxygenase enzymes (COX-1 and COX-2) By targeting these enzymes Bromfenac Sodium disrupts prostaglandin biosynthesis subsequently modulating inflammatory pathways and responses In biomedical research Bromfenac Sodium serves as a useful pharmacological tool to investigate inflammation signaling pathways and prostaglandin-mediated processes in various experimental models
Sigma Aldrich Fine Chemicals Biosciences 1-Dodecanol reagent grade, 98% | 112-53-8 | MFCD00004753 | 500G
1-Dodecanol reagent grade, 98% | Purity: 98% | Mol Wt: 186.33 | 112-53-8 | MFCD00004753 | 500G
Apexbio Technology LLC Diclofenac 15307-86-5 10mM (in 1mL DMSO)
Diclofenac (CAS 15307-86-5) is a phenylacetic acid derivative classified as a non-steroidal anti-inflammatory drug (NSAID) It exerts its biological activity by inhibiting cyclooxygenase (COX)-1 and COX-2 enzymes thereby suppressing prostaglandin synthesis that mediates inflammation and pain signaling Structurally the incorporation of two ortho chlorine atoms on the phenyl ring increases molecular rigidity which has been associated with enhanced potency Diclofenac is widely used in research to study inflammatory pathways pain mechanisms and as a reference compound in the evaluation of cyclooxygenase inhibition and potential gastrointestinal protective strategies in combination therapies
Medchemexpress LLC Neratinib (Standard) | 698387-09-6 | MFCD28073539 | 99.25% | 557.04 | 50 MG
Neratinib (Standard) is the analytical standard of Neratinib, intended for research and analytical applications. It is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively. This compound is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS as a reference standard.
- Analytical standard for Neratinib.
- Intended for research and analytical applications.
- Orally available.
- Irreversible.
- Highly selective HER2 and EGFR inhibitor.
- IC50s of 59 nM for HER2 and 92 nM for EGFR.
- Used as a reference standard in HPLC, GC, and MS research experiments.
Medchemexpress LLC Neratinib | 698387-09-6 | MFCD09752958 | 99.9% | 557.0 g/mol | 1 ML
Neratinib (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively.
- Inhibits proliferation of cell lines with high HER-2 levels.
- Less active in cell lines not expressing HER-2 or EGFR.
- Arrests cell cycle at G1-S phase.
- Causes inhibition of MAPK and Akt phosphorylation, down-regulation of cyclin D1 levels, and induction of p27.
- Shows anticancer activities against cancer cells expressing high levels of HER-2 or EGFR in vivo.
- Reduces tumor growth in a dose-dependent manner in xenografts.
- Inhibits phosphorylation of HER-2 in xenografts.
Medchemexpress LLC Curcumin-β-d-glucuronide | 227466-72-0 | MFCD28963761 | 98.0% | 544.50 | 1 ML
Curcumin-β-d-glucuronide is a major metabolite after oral intake of Curcumin, found in hepatic tissue and portal blood. It is used for research on colon cancer and has demonstrated anticancer properties in mouse tumor models and human metastatic colorectal cancer cell lines by promoting apoptosis. It also shows potential as a colon cancer prevention agent and possesses anti-inflammatory attributes by inhibiting prostaglandin E2 (PGE2) levels.
- Major metabolite of curcumin
- Exhibits anticancer properties
- Promotes apoptosis in cancer cells
- Potential colon cancer prevention agent
- Possesses anti-inflammatory attributes
- Inhibits prostaglandin E2 (PGE2) levels
Medchemexpress LLC Folic acid methyl ester | 1348988-65-7 | 99.1% | 455.42 | 5 MG
Folic acid methyl ester is a methyl ester metabolite of folic acid that can be used in the study of neuropsychiatric conditions, such as depression.
- It is a methyl ester metabolite of folic acid.
- It can be used in the study of neuropsychiatric conditions.
- It has potential application in research related to depression.
- It is available for research use only.
Medchemexpress LLC 2,6-Piperidinedione, 3-(4-bromo-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- | 2093387-36-9 | 99.86% | 323.14 | 250 MG
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, utilized in the recruitment of CRBN protein. It can be linked to a ligand for protein by a linker to create PROTACs.
- Analog of cereblon (CRBN) ligand for E3 ubiquitin ligase
- Used in the recruitment of CRBN protein
- Can be connected to form PROTACs, which are inducers of ubiquitination-mediated degradation of cancer-promoting proteins
TARGETMOL CHEMICALS INC NIRAPARIB TOSYLATE 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor. purity: 99%
Cayman Chemical Salbutamol-d9 500ug
An internal standard for the quantification of salbutamol by GC- or LC-MS
Cayman Chemical Olanzapine-related Compound B
A potential impurity found in commercial preparations of olanzapine; a degradation product formed by exposure to oxidative stress
Sigma Aldrich Fine Chemicals Biosciences Propyl parahydroxybenzoate European Pharmacopoeia (EP) Reference Standard | 94-13-3 | MFCD00002354 |
Propyl parahydroxybenzoate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 180.2 | 94-13-3 | MFCD00002354 |